AI Platform for Pipeline and Portfolio Development

Identify tailored 505(b)(2) brand-extension repurposing reformulation hybrid-pathway
opportunities in days.

Replace months of manual commercial, regulatory, IP, clinical, and formulation analysis with structured, evidence-backed opportunities your team can act on immediately.

Ready to deploy for US FDA · EU EMA · UK MHRA. On-premises & private-cloud deployment

rethink Tx · AI Platform
Opportunity Discovery Engine · 312 surfaced
01Reformulation: extended release86
02505(b)(2): new indication81
03Fixed-dose combination68
04Pediatric line extension61
Ranked by feasibility × strategic fit, evidence attached
Cross-Functional Feasibility · 50+ parameters
74
Regulatory
IP / FTO
Clinical
CMC
Commercial
Tentative: viable with bridging · all functions, in parallel
Option Path Modeling · scenario compare
505(b)(2)SuitabilityHybrid
Timeline~24 mo~30 mo~21 mo
Clinical burdenLowMinimalLow
Evidence riskLowModerateModerate
Expected valueHighModerateHighest
See the trade-offs before you commit capital
Review-ready outputs · source-linked
Pre-IND Interaction BriefingReady
Integrated Development Plan MemoReady
Target Product ProfileReady
IP & FTO AssessmentReady
Traceable to guidance & precedent: board, licensing & IND-ready
10×FasterFaster than manual cross-functional screening
3000+MoleculesApproved molecule universe of US FDA and EU EMA
50+ParametersEvaluation parameters across every function
100+AI AgentsCustomized Agents, Orchestrators and Catalogues
How rethink works

Orchestrated agents directed by your domain experts

Built specifically for your context, using private data and customized workflows, orchestrated agents move every opportunity through the cycle with the right precedent, evidence, alternatives, and traceability to accelerate portfolio decisions.

01Process
02Platform
Orchestrator
IP & Patent Regulatory Clinical Commercial Reformulation Repurposing RWE & Safety Financial CMC & Dev + Add any number of custom agents, any function
Expert sign-off
74
Conviction

Agents propose, your experts decide. We call this co-intelligence.

03Data Foundation
CatalogsMolecules, Indications, Pathways, Devices, Technologies, Annotations, Deficiencies, Precedents and Enablers.
DataOrange Book, DailyMed, Drugs@FDA, ClinicalTrials.gov, USPTO, PubMed, EMC, MHRA, ChEMBL, OpenTargets and your proprietary data.
Security & deployment

Deploys and runs inside your environment

Built for regulated pharma. Your proprietary pipeline data never has to leave your walls. Deployment, residency, and access stay under your control.

On-premises & private cloud

Full control over data residency and access within your own infrastructure. No forced multi-tenant cloud.

Isolated proprietary data

Internal pipeline data, historical assessments, and institutional records integrated with complete data isolation.

Configurable frameworks

Tailor scoring models, evaluation criteria, and workflows to fit how your team already works.

Traceable & auditable

Every opportunity links back to its source. Outputs are reviewable, versioned, and built to satisfy internal governance.

Aligned to: US FDA · EU EMA · UK MHRA Full data isolation Source-linked & auditable Enterprise security review supported
Revio success story

Single scan, a quarter of work, in days

In rethink's engagement with Revio, a single scan surfaced 300+ scored opportunities and 30+ development-ready strategies. That's a full cross-functional screening cycle compressed from months into days, with every output traceable to source.

Early-stage by design: we partner closely with a small number of teams and build the platform around real portfolio decisions. Founding team backgrounds span regulatory strategy, formulation science, and applied AI.

10×Faster than manual screening
300+Opportunities surfaced & scored
30+Development-ready strategies
50+Evaluation parameters per asset
Stakeholders

Pick the molecule. Defend the pathway. Own the outcome.

From first screen to IND-ready strategy, rethink works alongside the experts making the portfolio call.

Who uses it
Portfolio ManagerScreens, compares & decides
Business DevelopmentTarget screening & diligence
Commercial StrategyMarket & competitive read
Regulatory AffairsPathway strategy & precedent
IP & Patent StrategyLandscape & FTO analysis
Formulation & CMCReformulation feasibility
Clinical DevelopmentStudy design & evidence gaps
Organizations we serve
Large Pharma

Turn existing assets into new lifecycle and brand-extension opportunities.

Specialty Pharma

Build a sharper, evidence-backed pipeline faster than headcount allows.

Pharma Investors

Diligence target assets at a depth and speed manual processes can't reach.

Device & Tech Partners

Surface opportunities where your technology creates a defensible edge.

The team

Pharma and AI expertise, in one team

Decades inside pharma R&D, regulatory strategy, formulation science, and applied AI, with the NDAs, INDs, and marketed products to show for it.

Founders
Sreevatsa Natarajan
Sreevatsa NatarajanCo-Founder

Scientist-entrepreneur with 25+ years in global life-sciences R&D and business. Contributed to 15 NDAs, 25+ INDs, and numerous pre-INDs, 505(b)(2), hybrid, and ANDA programs, launching products across oncology, neurology, pain, inflammation, rare diseases, and infection. Holds dual master's degrees in chemistry and pharmacokinetics.

Previously PPD · Vertex · Glenmark · Sapien · Rhizen · Dr. Reddy's–Aurigene

Vinayak Dinesh
Vinayak DineshCo-Founder

Nearly 20 years in pharma product development and a serial entrepreneur. Has developed 20+ products for regulated markets, including first-to-file generics and 505(b)(2) programs, pairing deep biological domain knowledge with hands-on process design, scale-up, and commercialization. Founder of Novick Biosciences, a CDMO in India.

Previously Sanofi · GSK · Quintiles

Jyothi Kumar
Jyothi KumarCo-Founder

20+ years across investing, equity research, portfolio management, and startup building. Pairs financial rigor with strong product intuition to guide growth, pricing, and long-term value creation, and bridges data, technology, and market strategy to build scalable, domain-specific AI. CFA Level II with an MBA in finance.

Previously Centrum · Avendus Spark Capital · iLabs

Team
Dr. Indranil Mukhopadhyay
Dr. Indranil MukhopadhyayHead, Preclinical Development

20+ years in preclinical drug discovery, leading the preclinical characterization of five clinical candidates and steering cross-functional teams from early research through development-candidate selection. 30+ publications, 19 co-authored patents, and postdoctoral training at UMass Medical School and the NIH.

Previously Glenmark · Insilico Medicine · Enveda

Dr. Santhosh Kumar Mankala
Dr. Santhosh Kumar MankalaHead, Product Development

20+ years in product ideation and formulation development across parenteral, oral, and ophthalmic dosage forms for global markets. Contributed to 50+ generic and 505(b)(2) programs, including NCE-1, with multiple scientific-advice, pre-IND, and IND filings. 25+ publications, 10+ patents, and a PhD in pharmaceutical sciences.

Previously Tiefenbacher · Leiutis · Hetero

Pramod Nayeeni
Pramod NayeeniManager, Strategy Planning & Finance

IIM MBA with 7+ years in strategic finance and value creation. Builds enterprise forecasting and performance governance, investment-grade business cases, and group-level financial planning, including an IFRS-compliant five-year P&L for a billion-dollar business across five operating units.

Previously Cognizant · Aurore · Extrovis

Ayaan Zaidi
Ayaan ZaidiEngineering

Architects the end-to-end ReThink platform, fusing agentic AI workflows with pharma-grade controls for data, model lifecycle, orchestration, security, and governance. Builds large-scale data platforms with governed analytics and ML-ready feature stores. 2× founder.

Previously CERN · Reliance Jio · Vume Interactive · GSoC

Nag Janga
Nag JangaDesign

Design leader with 25+ years driving business value through user psychology, product strategy, and interface innovation. Has designed and scaled platforms for tens of millions of users across gaming, BFSI, startups, and the creator economy, building design teams and scalable design systems.

Previously Ness · Innova · Innopark · A23

Get started

See your next opportunity, evaluated end to end

Send us the molecule or the question. We'll take it from first screen to development-ready strategy, scored against your criteria.

Book a customized demo

Share a molecule, opportunity, or pathway and the founding team will schedule a demo.